6jcr

<table><tr><td colspan='2'>[[6jcr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_1 Adeno-associated virus - 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JCR FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcr OCA], [http://pdbe.org/6jcr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcr RCSB], [http://www.ebi.ac.uk/pdbsum/6jcr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcr ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.

 

== References ==

[[Category: Lou, Z]]

[[Category: Zhang, R]]

[[Category: Virus]]