1b0g

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{{Seed}}
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{{STRUCTURE_1b0g| PDB=1b0g | SCENE= }}
{{STRUCTURE_1b0g| PDB=1b0g | SCENE= }}
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'''CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX'''
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===CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX===
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==Overview==
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The T cell receptor (TCR), from a xeno-reactive murine cytotoxic T lymphocyte clone AHIII12.2, recognizes murine H-2Db complexed with peptide p1027 (FAPGVFPYM), as well as human HLA-A2.1 complexed with peptide p1049 (ALWGFFPVL). A commonly proposed model (the molecular mimicry model) used to explain TCR cross-reactivity suggests that the molecular surfaces of the recognized complexes are similar in shape, charge, or both, in spite of the primary sequence differences. To examine the mechanism of xeno-reactivity of AHIII12.2, we have determined the crystal structures of A2/p1049 and Db/p1027 to 2.5 A and 2.8 A resolution, respectively. The crystal structures show that the TCR footprint regions of the two class I complexes are significantly different in shape and charge. We propose that rather than simple molecular mimicry, unpredictable arrays of common and differential contacts on the two class I complexes are used for their recognition by the same TCR.
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The line below this paragraph, {{ABSTRACT_PUBMED_9892618}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9892618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9892618}}
==About this Structure==
==About this Structure==
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[[Category: Collins, E J.]]
[[Category: Collins, E J.]]
[[Category: Zhao, R.]]
[[Category: Zhao, R.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:55:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:58:49 2008''

Revision as of 14:58, 30 June 2008

Image:1b0g.png

Template:STRUCTURE 1b0g

CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX

Template:ABSTRACT PUBMED 9892618

About this Structure

1B0G is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1a9k. Full crystallographic information is available from OCA.

Reference

Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry., Zhao R, Loftus DJ, Appella E, Collins EJ, J Exp Med. 1999 Jan 18;189(2):359-70. PMID:9892618

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