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6nj8

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Current revision (09:21, 20 March 2024) (edit) (undo)
 
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<SX load='6nj8' size='340' side='right' viewer='molstar' caption='[[6nj8]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
<SX load='6nj8' size='340' side='right' viewer='molstar' caption='[[6nj8]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nj8]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"quasibacillus_thermotolerans"_(yang_et_al._2013)_verma_et_al._2017 "quasibacillus thermotolerans" (yang et al. 2013) verma et al. 2017]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NJ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nj8]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Quasibacillus_thermotolerans Quasibacillus thermotolerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NJ8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6n63|6n63]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QY95_01592 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1221996 "Quasibacillus thermotolerans" (Yang et al. 2013) Verma et al. 2017])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nj8 OCA], [https://pdbe.org/6nj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nj8 RCSB], [https://www.ebi.ac.uk/pdbsum/6nj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nj8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nj8 OCA], [http://pdbe.org/6nj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nj8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nj8 ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ENCAP_QUATH ENCAP_QUATH]
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Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron. Encapsulins, a class of protein-based organelles, have recently been implicated in microbial iron and redox metabolism. Here, we report the structural and mechanistic characterization of a 42 nm two-component encapsulin-based iron storage compartment from Quasibacillus thermotolerans. Using cryo-electron microscopy and x-ray crystallography, we reveal the assembly principles of a thermostable T = 4 shell topology and its catalytic ferroxidase cargo and show interactions underlying cargo-shell co-assembly. This compartment has an exceptionally large iron storage capacity storing over 23,000 iron atoms. Our results reveal a new approach for survival in diverse habitats with limited or fluctuating iron availability via an iron storage system able to store 10 to 20 times more iron than ferritin.
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Large protein organelles form a new iron sequestration system with high storage capacity.,Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA Elife. 2019 Jul 8;8. pii: 46070. doi: 10.7554/eLife.46070. PMID:31282860<ref>PMID:31282860</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6nj8" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chambers, M G]]
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[[Category: Quasibacillus thermotolerans]]
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[[Category: Giessen, T W]]
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[[Category: Chambers MG]]
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[[Category: Liao, M]]
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[[Category: Giessen TW]]
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[[Category: Orlando, B J]]
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[[Category: Liao M]]
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[[Category: Silver, P A]]
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[[Category: Orlando BJ]]
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[[Category: Encapsulin]]
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[[Category: Silver PA]]
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[[Category: Icosahedral]]
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[[Category: Imef]]
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[[Category: Iron storage]]
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[[Category: Metal transport]]
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Current revision

Encapsulin iron storage compartment from Quasibacillus thermotolerans

6nj8, resolution 3.85Å

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