We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1b0n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1b0n.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1b0n.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1b0n| PDB=1b0n | SCENE= }}
{{STRUCTURE_1b0n| PDB=1b0n | SCENE= }}
-
'''SINR PROTEIN/SINI PROTEIN COMPLEX'''
+
===SINR PROTEIN/SINI PROTEIN COMPLEX===
-
==Overview==
+
<!--
-
Spore formation is an extreme response of some bacteria to adversity. In Bacillus subtilis the proteins of the sin, sporulation inhibition, region form a component of an elaborate molecular circuitry that regulates the commitment to sporulation. SinR is a tetrameric repressor protein that binds to the promoters of genes essential for entry into sporulation and prevents their transcription. This repression is overcome through the activity of SinI, which disrupts the SinR tetramer through the formation of a SinI-SinR heterodimer. The interactions governing this curious quaternary transition are revealed in the crystal structure of the SinI-SinR complex. The most striking, and unexpected, finding is that the tertiary structure of the DNA-binding domain of SinR is identical with that of the corresponding domains of the repressor proteins, CI and Cro, of bacteriophage 434 that regulate lysis/lysogeny. This structural similarity greatly exceeds that between SinR and any bacterial protein or between the 434 repressor proteins and their homologues in the closely related bacteriophage lambda. The close evolutionary relationship implied by the structures of SinR and the 434 repressors provokes both comparison of their functions and a speculative consideration of the intriguing possibility of an evolutionary link between the two adaptive responses, sporulation and prophage induction.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9799632}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9799632 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9799632}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Sporulation]]
[[Category: Sporulation]]
[[Category: Transcription regulator]]
[[Category: Transcription regulator]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:55:38 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:59:36 2008''

Revision as of 14:59, 30 June 2008

Image:1b0n.png

Template:STRUCTURE 1b0n

SINR PROTEIN/SINI PROTEIN COMPLEX

Template:ABSTRACT PUBMED 9799632

About this Structure

1B0N is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex., Lewis RJ, Brannigan JA, Offen WA, Smith I, Wilkinson AJ, J Mol Biol. 1998 Nov 13;283(5):907-12. PMID:9799632

Page seeded by OCA on Mon Jun 30 17:59:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b0n"
Personal tools