6pv8

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<SX load='6pv8' size='340' side='right' viewer='molstar' caption='[[6pv8]], [[Resolution|resolution]] 3.87&Aring;' scene=''>
<SX load='6pv8' size='340' side='right' viewer='molstar' caption='[[6pv8]], [[Resolution|resolution]] 3.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pv8]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PV8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PV8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pv8]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O11 Escherichia coli O11], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PV8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P1M:(3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine'>P1M</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.87&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA3, NACHRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CHRNB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P1M:(3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine'>P1M</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pv8 OCA], [http://pdbe.org/6pv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pv8 RCSB], [http://www.ebi.ac.uk/pdbsum/6pv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pv8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pv8 OCA], [https://pdbe.org/6pv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pv8 RCSB], [https://www.ebi.ac.uk/pdbsum/6pv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pv8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACHB4_HUMAN ACHB4_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [[http://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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[https://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pv8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pv8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetyl choline receptor 3D structures|Acetyl choline receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Escherichia coli O11]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cabuco, R]]
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[[Category: Cabuco R]]
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[[Category: Gharpure, A]]
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[[Category: Gharpure A]]
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[[Category: Hibbs, R E]]
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[[Category: Hibbs RE]]
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[[Category: Howard, R J]]
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[[Category: Howard RJ]]
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[[Category: Lindahl, E]]
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[[Category: Lindahl E]]
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[[Category: Noviello, C M]]
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[[Category: Noviello CM]]
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[[Category: Teng, J]]
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[[Category: Teng J]]
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[[Category: Walsh, R M]]
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[[Category: Walsh RM]]
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[[Category: Zaveri, N T]]
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[[Category: Zaveri NT]]
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[[Category: Zhuang, Y]]
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[[Category: Zhuang Y]]
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[[Category: Cys-loop receptor]]
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[[Category: Ligand-gated ion channel]]
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[[Category: Membrane protein]]
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[[Category: Nicotinic acetylcholine receptor]]
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Current revision

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

6pv8, resolution 3.87Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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