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6ui9

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<SX load='6ui9' size='340' side='right' viewer='molstar' caption='[[6ui9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<SX load='6ui9' size='340' side='right' viewer='molstar' caption='[[6ui9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ui9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UI9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UI9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ui9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UI9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ui9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ui9 OCA], [https://pdbe.org/6ui9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ui9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ui9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ui9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ui9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ui9 OCA], [http://pdbe.org/6ui9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ui9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ui9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ui9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref>
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[[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ui9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ui9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
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[[Category: ATP citrate synthase]]
 
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]

Revision as of 10:08, 7 July 2021

Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate

6ui9, resolution 3.10Å

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OCA

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