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| | <SX load='6umm' size='340' side='right' viewer='molstar' caption='[[6umm]], [[Resolution|resolution]] 3.70Å' scene=''> | | <SX load='6umm' size='340' side='right' viewer='molstar' caption='[[6umm]], [[Resolution|resolution]] 3.70Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6umm]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UMM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6umm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UMM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6umm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umm OCA], [http://pdbe.org/6umm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6umm RCSB], [http://www.ebi.ac.uk/pdbsum/6umm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6umm ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6umm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umm OCA], [https://pdbe.org/6umm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6umm RCSB], [https://www.ebi.ac.uk/pdbsum/6umm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6umm ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/ECCC3_MYCS2 ECCC3_MYCS2]] Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.<ref>PMID:19846780</ref> <ref>PMID:24803520</ref> [[http://www.uniprot.org/uniprot/ECCE3_MYCS2 ECCE3_MYCS2]] Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.<ref>PMID:19846780</ref> <ref>PMID:24803520</ref> [[http://www.uniprot.org/uniprot/ECCB3_MYCS2 ECCB3_MYCS2]] An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.[UniProtKB:P9WNR7]<ref>PMID:19846780</ref> <ref>PMID:24803520</ref> [[http://www.uniprot.org/uniprot/ECCD3_MYCS2 ECCD3_MYCS2]] Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.<ref>PMID:19846780</ref> <ref>PMID:24803520</ref> | + | [https://www.uniprot.org/uniprot/ECCE3_MYCS2 ECCE3_MYCS2] Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.<ref>PMID:19846780</ref> <ref>PMID:24803520</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | </SX> | | </SX> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Mycs2]] | + | [[Category: Mycolicibacterium smegmatis MC2 155]] |
| - | [[Category: Poweleit, N]] | + | [[Category: Poweleit N]] |
| - | [[Category: Rosenberg, O S]] | + | [[Category: Rosenberg OS]] |
| - | [[Category: Complex]]
| + | |
| - | [[Category: Esx]]
| + | |
| - | [[Category: Membrane protein]]
| + | |
| - | [[Category: Mycobacteria]]
| + | |
| - | [[Category: Secretion system]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| - | [[Category: Type vii secretion system]]
| + | |
| Structural highlights
Function
ECCE3_MYCS2 Part of the ESX-3 specialized secretion system, which is required for siderophore-mediated iron acquisition and for the secretion of EsxH and EsxG.[1] [2]
References
- ↑ Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18792-7. doi:, 10.1073/pnas.0900589106. Epub 2009 Oct 21. PMID:19846780 doi:http://dx.doi.org/10.1073/pnas.0900589106
- ↑ Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. Mycobacterial Esx-3 requires multiple components for iron acquisition. MBio. 2014 May 6;5(3):e01073-14. doi: 10.1128/mBio.01073-14. PMID:24803520 doi:http://dx.doi.org/10.1128/mBio.01073-14
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