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6uwm

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Current revision (14:34, 6 March 2024) (edit) (undo)
 
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<SX load='6uwm' size='340' side='right' viewer='molstar' caption='[[6uwm]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
<SX load='6uwm' size='340' side='right' viewer='molstar' caption='[[6uwm]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6uwm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aerpx Aerpx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UWM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UWM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6uwm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix Aeropyrum pernix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UWM FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APE_0955 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56636 AERPX])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uwm OCA], [http://pdbe.org/6uwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uwm RCSB], [http://www.ebi.ac.uk/pdbsum/6uwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uwm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uwm OCA], [https://pdbe.org/6uwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uwm RCSB], [https://www.ebi.ac.uk/pdbsum/6uwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uwm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KVAP_AERPE KVAP_AERPE]] Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
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[https://www.uniprot.org/uniprot/KVAP_AERPE KVAP_AERPE] Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Conductance in voltage-gated ion channels is regulated by membrane voltage through structural domains known as voltage sensors. A single structural class of voltage sensor domain exists, but two different modes of voltage sensor attachment to the pore occur in nature: domain-swapped and non-domain-swapped. Since the more thoroughly studied Kv1-7, Nav and Cav channels have domain-swapped voltage sensors, much less is known about non-domain-swapped voltage-gated ion channels. In this paper, using cryo-EM, we show that KvAP from Aeropyrum pernix has non-domain-swapped voltage sensors as well as other unusual features. The new structure, together with previous functional data, suggests that KvAP and the Shaker channel, to which KvAP is most often compared, probably undergo rather different voltage-dependent conformational changes when they open.
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Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.,Tao X, MacKinnon R Elife. 2019 Nov 22;8. pii: 52164. doi: 10.7554/eLife.52164. PMID:31755864<ref>PMID:31755864</ref>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6uwm" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Aerpx]]
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[[Category: Aeropyrum pernix]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: MacKinnon, R]]
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[[Category: MacKinnon R]]
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[[Category: Tao, X]]
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[[Category: Tao X]]
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[[Category: Non-domain-swapped]]
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[[Category: Transport protein]]
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[[Category: Voltage-gated potassium channel]]
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Current revision

Single particle cryo-EM structure of KvAP

6uwm, resolution 5.90Å

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