6kvb

<StructureSection load='6kvb' size='340' side='right'caption='[[6kvb]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[6kvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KVB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KVB FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kvb OCA], [http://pdbe.org/6kvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kvb RCSB], [http://www.ebi.ac.uk/pdbsum/6kvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kvb ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

G-rich DNA sequences with tracts of three or more continuous guanines (G&gt;/=3) are known to have high propensity to adopt stable G-quadruplex (G4) structures. Bioinformatic analyses suggest high prevalence of G-rich sequences with short G-tracts (G&lt;/=2) in the human genome. However, due to limited structural studies, the folding principles of such sequences remain largely unexplored and hence poorly understood. Here, we present the solution NMR structure of a sequence named AT26 consisting of irregularly spaced G2 tracts and two isolated single guanines. The structure is a four-layered G4 featuring two bi-layered blocks, locked between themselves in an unprecedented fashion making it a stable scaffold. In addition to edgewise and propeller-type loops, AT26 also harbors two V-shaped loops: a 2-nt V-shaped loop spanning two G-tetrad layers and a 0-nt V-shaped loop spanning three G-tetrad layers, which are named as VS- and VR-loop respectively, based on their distinct structural features. The intra-lock motif can be a basis for extending the G-tetrad core and a very stable intra-locked G4 can be formed by a sequence with G-tracts of various lengths including several G2 tracts. Findings from this study will aid in understanding the folding of G4 topologies from sequences containing irregularly spaced multiple short G-tracts.

Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.,Maity A, Winnerdy FR, Chang WD, Chen G, Phan AT Nucleic Acids Res. 2020 Feb 26. pii: 5758051. doi: 10.1093/nar/gkaa008. PMID:32100003<ref>PMID:32100003</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 6kvb" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Chang, W D]]

[[Category: Chen, G]]

[[Category: Maity, A]]

[[Category: Phan, A T]]

[[Category: Winnerdy, F R]]

[[Category: Dna]]

[[Category: Nmr spectroscopy]]