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1b2v

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[[Image:1b2v.jpg|left|200px]]
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{{STRUCTURE_1b2v| PDB=1b2v | SCENE= }}
{{STRUCTURE_1b2v| PDB=1b2v | SCENE= }}
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'''HEME-BINDING PROTEIN A'''
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===HEME-BINDING PROTEIN A===
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==Overview==
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Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host's iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release.
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{{ABSTRACT_PUBMED_10360351}}
==About this Structure==
==About this Structure==
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[[Category: Heme acquisition]]
[[Category: Heme acquisition]]
[[Category: Iron metabolism]]
[[Category: Iron metabolism]]
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Revision as of 15:06, 30 June 2008

Image:1b2v.png

Template:STRUCTURE 1b2v

HEME-BINDING PROTEIN A

Template:ABSTRACT PUBMED 10360351

About this Structure

1B2V is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

The crystal structure of HasA, a hemophore secreted by Serratia marcescens., Arnoux P, Haser R, Izadi N, Lecroisey A, Delepierre M, Wandersman C, Czjzek M, Nat Struct Biol. 1999 Jun;6(6):516-20. PMID:10360351

Page seeded by OCA on Mon Jun 30 18:06:22 2008

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