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2jb0

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<StructureSection load='2jb0' size='340' side='right'caption='[[2jb0]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='2jb0' size='340' side='right'caption='[[2jb0]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jb0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecow3 Ecow3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JB0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jb0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecow3 Ecow3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JB0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ayi|1ayi]], [[1cei|1cei]], [[1mz8|1mz8]], [[1ujz|1ujz]], [[1unk|1unk]], [[1znv|1znv]], [[2erh|2erh]], [[7cei|7cei]], [[1m08|1m08]], [[1pt3|1pt3]], [[1zns|1zns]], [[2axc|2axc]], [[2ivh|2ivh]], [[2jaz|2jaz]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ayi|1ayi]], [[1cei|1cei]], [[1mz8|1mz8]], [[1ujz|1ujz]], [[1unk|1unk]], [[1znv|1znv]], [[2erh|2erh]], [[7cei|7cei]], [[1m08|1m08]], [[1pt3|1pt3]], [[1zns|1zns]], [[2axc|2axc]], [[2ivh|2ivh]], [[2jaz|2jaz]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jb0 OCA], [http://pdbe.org/2jb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jb0 RCSB], [http://www.ebi.ac.uk/pdbsum/2jb0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jb0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jb0 OCA], [https://pdbe.org/2jb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jb0 RCSB], [https://www.ebi.ac.uk/pdbsum/2jb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jb0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA. [[http://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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[[https://www.uniprot.org/uniprot/IMM7_ECOLX IMM7_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE7 encoding colicin E7, against colicin E7, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity. Dimeric ImmE7 may possess a RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream ceiE7 gene as well as degradation of the upstream ceaE7 mRNA. [[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 08:05, 19 January 2022

CRYSTAL STRUCTURE OF THE MUTANT H573A OF THE NUCLEASE DOMAIN OF COLE7 IN COMPLEX WITH IM7

PDB ID 2jb0

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