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1b3p

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[[Image:1b3p.gif|left|200px]]
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{{STRUCTURE_1b3p| PDB=1b3p | SCENE= }}
{{STRUCTURE_1b3p| PDB=1b3p | SCENE= }}
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'''5'-D(*GP*GP*AP*GP*GP*AP*T)-3''''
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===5'-D(*GP*GP*AP*GP*GP*AP*T)-3'===
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==Overview==
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BACKGROUND: Triplet repeat sequences are of considerable biological importance as the expansion of such tandem arrays can lead to the onset of a range of human diseases. Such sequences can self-pair via mismatch alignments to form higher order structures that have the potential to cause replication blocks, followed by strand slippage and sequence expansion. The all-purine d(GGA)n triplet repeat sequence is of particular interest because purines can align via G.G, A.A and G.A mismatch formation. RESULTS: We have solved the structure of the uniformly 13C,15N-labeled d(G1-G2-A3-G4-G5-A6-T7) sequence in 10 mM Na+ solution. This sequence adopts a novel twofold-symmetric duplex fold where interlocked V-shaped arrowhead motifs are aligned solely via interstrand G1.G4, G2.G5 and A3.A6 mismatch formation. The tip of the arrowhead motif is centered about the p-A3-p step, and symmetry-related local parallel-stranded duplex domains are formed by the G1-G2-A3 and G4-G5-A6 segments of partner strands. CONCLUSIONS: The purine-rich (GGA)n triplet repeat sequence is dispersed throughout the eukaryotic genome. Several features of the arrowhead duplex motif for the (GGA)2 triplet repeat provide a unique scaffold for molecular recognition. These include the large localized bend in the sugar-phosphate backbones, the segmental parallel-stranded alignment of strands and the exposure of the Watson-Crick edges of several mismatched bases.
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The line below this paragraph, {{ABSTRACT_PUBMED_10425682}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10425682 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10425682}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].
==Reference==
==Reference==
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[[Category: Uniform 13c]]
[[Category: Uniform 13c]]
[[Category: V-shaped backbone]]
[[Category: V-shaped backbone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:25 2008''

Revision as of 15:10, 30 June 2008

Image:1b3p.png

Template:STRUCTURE 1b3p

5'-D(*GP*GP*AP*GP*GP*AP*T)-3'

Template:ABSTRACT PUBMED 10425682

About this Structure

Full experimental information is available from OCA.

Reference

Interlocked mismatch-aligned arrowhead DNA motifs., Kettani A, Bouaziz S, Skripkin E, Majumdar A, Wang W, Jones RA, Patel DJ, Structure. 1999 Jul 15;7(7):803-15. PMID:10425682

Page seeded by OCA on Mon Jun 30 18:10:25 2008

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