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6t2t

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Current revision (12:53, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6t2t' size='340' side='right'caption='[[6t2t]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='6t2t' size='340' side='right'caption='[[6t2t]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6t2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T2T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6t2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T2T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GstE14, GSTD14-14, nobo, CG4688 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2t OCA], [https://pdbe.org/6t2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t2t RCSB], [https://www.ebi.ac.uk/pdbsum/6t2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2t OCA], [http://pdbe.org/6t2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t2t RCSB], [http://www.ebi.ac.uk/pdbsum/6t2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2t ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>
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[https://www.uniprot.org/uniprot/GSTEE_DROME GSTEE_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref> <ref>PMID:25300303</ref> <ref>PMID:25344753</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6t2t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6t2t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Glutathione transferase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gonis, E]]
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[[Category: Gonis E]]
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[[Category: Lindstrom, H]]
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[[Category: Lindstrom H]]
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[[Category: Mannervik, B]]
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[[Category: Mannervik B]]
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[[Category: Neiers, F]]
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[[Category: Neiers F]]
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[[Category: Sjodin, B]]
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[[Category: Sjodin B]]
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[[Category: Skerlova, J]]
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[[Category: Skerlova J]]
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[[Category: Stenmark, P]]
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[[Category: Stenmark P]]
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[[Category: Steroid isomerase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Drosophila melanogaster glutathione S-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol

PDB ID 6t2t

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