5e68

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Current revision (06:14, 5 July 2023) (edit) (undo)
 
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<StructureSection load='5e68' size='340' side='right'caption='[[5e68]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='5e68' size='340' side='right'caption='[[5e68]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E68 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E68 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1joe|1joe]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e68 OCA], [https://pdbe.org/5e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e68 RCSB], [https://www.ebi.ac.uk/pdbsum/5e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e68 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">luxS, STY2943, t2714 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-ribosylhomocysteine_lyase S-ribosylhomocysteine lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.21 4.4.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e68 OCA], [http://pdbe.org/5e68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e68 RCSB], [http://www.ebi.ac.uk/pdbsum/5e68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e68 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LUXS_SALTI LUXS_SALTI]] Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).[HAMAP-Rule:MF_00091]
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[https://www.uniprot.org/uniprot/LUXS_SALTI LUXS_SALTI] Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).[HAMAP-Rule:MF_00091]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus typhi schroeter 1886]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: S-ribosylhomocysteine lyase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
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[[Category: Arockiasamy, A]]
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[[Category: Arockiasamy A]]
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[[Category: Perumal, P]]
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[[Category: Perumal P]]
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[[Category: Raina, R]]
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[[Category: Raina R]]
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[[Category: SundaraBaalaji, N]]
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[[Category: SundaraBaalaji N]]
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[[Category: Lux]]
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[[Category: Lyase]]
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[[Category: Quroum sensing protein]]
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[[Category: Salmonella typhi]]
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Current revision

High resolution crystal structure of LuxS - Quorum sensor molecular complex from Salmonella typhi at 1.58 Angstroms

PDB ID 5e68

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