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5eat

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Current revision (06:51, 9 August 2023) (edit) (undo)
 
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<StructureSection load='5eat' size='340' side='right'caption='[[5eat]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5eat' size='340' side='right'caption='[[5eat]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EAT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eat]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eat OCA], [http://pdbe.org/5eat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eat RCSB], [http://www.ebi.ac.uk/pdbsum/5eat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eat ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHP:1-HYDROXY-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENE+PHOSPHONIC+ACID'>FHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eat OCA], [https://pdbe.org/5eat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eat RCSB], [https://www.ebi.ac.uk/pdbsum/5eat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eat ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
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[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: American tobacco]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Back, K]]
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[[Category: Nicotiana tabacum]]
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[[Category: Chappell, J]]
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[[Category: Back K]]
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[[Category: Noel, J P]]
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[[Category: Chappell J]]
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[[Category: Starks, C M]]
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[[Category: Noel JP]]
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[[Category: 5-epi-aristolochene synthase]]
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[[Category: Starks CM]]
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[[Category: Isoprenoid biosynthesis]]
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[[Category: Isoprenoid cyclase]]
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[[Category: Isoprenoid synthase]]
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[[Category: Natural products biosynthesis]]
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Current revision

5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM WITH SUBSTRATE ANALOG FARNESYL HYDROXYPHOSPHONATE

PDB ID 5eat

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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