Epsin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> describing Jmol <ref>PMID:21638687</ref> to the rescue. == Function == == Disease ==...) |
|||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='5on7' size='340' side='right' caption='Caption for this structure' scene=''> | |
| - | <StructureSection load=' | + | |
| - | + | ||
== Function == | == Function == | ||
| + | |||
| + | '''Epsin''' (Eps) is essential for cell viability in yeast and for embryo development in higher eukaryotes. Epsins function as adaptors by recognizing ubiquitinated cargo and as endocytic accessory proteins by contributing to endocytic network stability regulation and membrane bending<ref>PMID:22942912</ref>. The N-terminus domain of Eps is called Epsin N-Terminal Homology domain (ENTH). ENTH is a highly conserved ca. 150 amino acid-long domain which binds phosphatidylinoitol 4,5-bisphosphate which is a lipid enriched at regions of plasma membrane including endocytic sites. | ||
== Disease == | == Disease == | ||
| Line 23: | Line 23: | ||
[[5lp0]] - Eps-1 ENTH domain - zebrafish<br /> | [[5lp0]] - Eps-1 ENTH domain - zebrafish<br /> | ||
[[5onf]], [[5loz]] - yEps-1 ENTH domain - yeast<br /> | [[5onf]], [[5loz]] - yEps-1 ENTH domain - yeast<br /> | ||
| - | [[5ahv]] - yEps-1 ENTH domain + SLA2 ANTH domain - | + | [[5ahv]] - yEps-1 ENTH domain + SLA2 ANTH domain - Cryo EM<br /> |
[[6enr]], [[4gzc]] - yEps-2 ENTH domain<br /> | [[6enr]], [[4gzc]] - yEps-2 ENTH domain<br /> | ||
[[4gzd]] - yEps-2 ENTH domain (mutant)<br /> | [[4gzd]] - yEps-2 ENTH domain (mutant)<br /> | ||
Revision as of 08:08, 24 April 2020
| |||||||||||
3D structures of epsin
Updated on 24-April-2020
1inz - hEps epsin N-terminal homology domain ENTH 1-144 - human NMR
1xgw, 2qy7 - hEps-4 ENTH domain
1edu, 1eyh - rEps-1 ENTH domain - rat
1h0a - rEps ENTH domain + inositol triphosphate
5lp0 - Eps-1 ENTH domain - zebrafish
5onf, 5loz - yEps-1 ENTH domain - yeast
5ahv - yEps-1 ENTH domain + SLA2 ANTH domain - Cryo EM
6enr, 4gzc - yEps-2 ENTH domain
4gzd - yEps-2 ENTH domain (mutant)
5on7 - yEps-2 ENTH domain + phosphatidylinoitol bisphosphate
3onk - yEps-3 ENTH domain
3onl - yEps-3 ENTH domain + T-SNARE VTII HABC domain
5j08, 5cmw, 5cmy - yEps-5 ENTH domain
References
- ↑ Sen A, Madhivanan K, Mukherjee D, Aguilar RC. The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts. 2012 Apr;3(2):117-126. doi: 10.1515/bmc-2011-0060. PMID:22942912 doi:http://dx.doi.org/10.1515/bmc-2011-0060
