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Amino acid composition
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The ''amino acid composition'' of a protein refers to the percentages of each amino acid in the sequence of that protein. The percentage, sometimes called the Mole percentage, is calculated as the number of a given amino acid divided by the total number of amino acids in the protein chain or molecule. | The ''amino acid composition'' of a protein refers to the percentages of each amino acid in the sequence of that protein. The percentage, sometimes called the Mole percentage, is calculated as the number of a given amino acid divided by the total number of amino acids in the protein chain or molecule. | ||
| - | The strongest predictor of amino acid composition is the GC-content of the organism's genome<ref name="tekala-genomes">PMID: 12384285</ref>. | + | The strongest predictor of amino acid composition is the GC-content of the organism's genome<ref name="tekala-genomes">PMID: 12384285</ref>. Other, weaker influences are growth temperatures (mesophily/thermophily/hyperthermophily), |
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| + | Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine. This likely relates to the larger number of [[salt bridges]] in proteins of thermophiles, believe to contribute to thermostability. | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 23:24, 23 April 2020
The amino acid composition of a protein refers to the percentages of each amino acid in the sequence of that protein. The percentage, sometimes called the Mole percentage, is calculated as the number of a given amino acid divided by the total number of amino acids in the protein chain or molecule.
The strongest predictor of amino acid composition is the GC-content of the organism's genome[1]. Other, weaker influences are growth temperatures (mesophily/thermophily/hyperthermophily),
Thermophiles have more glutamic acid (with reduction in glutamine), and more lysine and arginine. This likely relates to the larger number of salt bridges in proteins of thermophiles, believe to contribute to thermostability.
References
- ↑ Tekaia F, Yeramian E, Dujon B. Amino acid composition of genomes, lifestyles of organisms, and evolutionary trends: a global picture with correspondence analysis. Gene. 2002 Sep 4;297(1-2):51-60. doi: 10.1016/s0378-1119(02)00871-5. PMID:12384285 doi:http://dx.doi.org/10.1016/s0378-1119(02)00871-5
