Sandbox 30007

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== Function ==
== Function ==
'''Non-structural protein 7 (nsp7)'''
'''Non-structural protein 7 (nsp7)'''
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Forms a hexadecamer with [[SARS-CoV-2_protein_NSP8|nsp8]] (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>
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Forms a hexadecamer with [[SARS-CoV-2_protein_NSP8|nsp8]] (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>[http://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>
== Disease ==
== Disease ==

Revision as of 07:26, 26 April 2020

NSP7 model from Zhang Lab (TM Score=.89)

References

  1. Modeling of the SARS-COV-2 Genome
  2. Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
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