User:Oluwapeluwa Sangoseni/Sandbox 1

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Multifunctional roles of thrombin.
Multifunctional roles of thrombin.
Ann Clin Lab Sci. 1999; 29: 275-280
Ann Clin Lab Sci. 1999; 29: 275-280
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</ref>. This is required to prevent excessive blood clotting, which would be problematic as required blood flow may be impeded. Thrombin also regulates fibrinolysis by activating carboxypeptidase B2, also known as thrombin activatable fibrinolysis inhibitor. With this wide array of necessary functions, thrombin is a very important enzyme for maintenance of our bodies. <ref>6</ref>
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</ref>. This is required to prevent excessive blood clotting, which would be problematic as required blood flow may be impeded. Thrombin also regulates fibrinolysis by activating carboxypeptidase B2, also known as thrombin activatable fibrinolysis inhibitor. With this wide array of necessary functions, thrombin is a very important enzyme for maintenance of our bodies.
== Function and Structure ==
== Function and Structure ==

Revision as of 02:32, 28 April 2020

6P9U, Crystal Structure of Human Thrombin Mutant W215A

6P9U, resolution 3.38Å

Drag the structure with the mouse to rotate

References

  1. Le Bonniec, B. F., &Walenga, J. M. (n.d.). Thrombin. Retrieved March 22, 2020, from https://www.sciencedirect.com/topics/medicine-and-dentistry/thrombin
  2. Le Bonniec, B. F., &Walenga, J. M. (n.d.). Thrombin. Retrieved March 22, 2020, from https://www.sciencedirect.com/topics/medicine-and-dentistry/thrombin
  3. S. Multifunctional roles of thrombin. Ann Clin Lab Sci. 1999; 29: 275-280
  4. Pelc, L.a., et al. “Crystal Structure of Human Thrombin Mutant W215A.” 2019, doi:10.2210/pdb6p9u/pdb.
  5. Pelc, L.a., et al. “Crystal Structure of Human Thrombin Mutant W215A.” 2019, doi:10.2210/pdb6p9u/pdb.
  6. Pelc, L. A., Koester, S. K., Chen, Z., Gistover, N. E., & Di Cera, E. (2019). Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Scientific reports, 9(1), 12304. https://doi.org/10.1038/s41598-019-48839-1
  7. Pelc, L. A., Koester, S. K., Chen, Z., Gistover, N. E., & Di Cera, E. (2019). Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Scientific reports, 9(1), 12304. https://doi.org/10.1038/s41598-019-48839-1
  8. Bunce, M. W., Toso, R., &Camire, R. M. (2011). Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood, 117(1), 290–298. https://doi.org/10.1182/blood-2010-08-300756
  9. Berny-Lang, M. A., Hurst, S., Tucker, E. I., Pelc, L. A., Wang, R. K., Hurn, P. D., Di Cera, E., McCarty, O. J., & Gruber, A. (2011). Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke, 42(6), 1736–1741. https://doi.org/10.1161/STROKEAHA.110.603811
  10. The Internet Stroke Center. (n.d.). Retrieved March 22, 2020, from http://www.strokecenter.org/patients/about-stroke/ischemic-stroke/
  11. Gruber, A., Cantwell, A. M., Cera, E. D., & Hanson, S. R. (2002). The Thrombin Mutant W215A/E217A Shows Safe and Potent Anticoagulant and Antithrombotic Effectsin Vivo. Journal of Biological Chemistry,277(31), 27581-27584. doi:10.1074/jbc.c200237200

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