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1b5n

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[[Image:1b5n.gif|left|200px]]
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{{STRUCTURE_1b5n| PDB=1b5n | SCENE= }}
{{STRUCTURE_1b5n| PDB=1b5n | SCENE= }}
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'''NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS'''
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===NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS===
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==Overview==
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The structure of the recently identified plasmatocyte spreading peptide from the moth Pseudoplusia includens (PSP1) has been determined by NMR spectroscopy. This novel insect cytokine consists of 23 amino acid residues and a single disulfide bond. Torsion angle dynamics calculations utilizing a total of 337 distance constraints yielded an ensemble of 30 structures with an average backbone root mean square deviation for residues 7-22 of 0.18 A from the mean structure. The structure consists of a disordered N-terminal region and a well defined core that is stabilized by numerous hydrophobic interactions and a short beta-hairpin. Structural comparisons confirm that PSP1 adopts an epidermal growth factor (EGF)-like fold with close similarity to the C-terminal subdomain of EGF-like module 5 of human thrombomodulin. The combination of the three-dimensional structure of PSP1 and the extensive literature on EGF-receptor interactions should accelerate the process of identifying the specific residues responsible for receptor binding activity of this family of immunoregulatory peptides.
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The line below this paragraph, {{ABSTRACT_PUBMED_9988679}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9988679 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9988679}}
==About this Structure==
==About this Structure==
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1B5N is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5N OCA].
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1B5N is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B5N OCA].
==Reference==
==Reference==
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[[Category: Insect cytokine]]
[[Category: Insect cytokine]]
[[Category: Plasmatocyte-spreading]]
[[Category: Plasmatocyte-spreading]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:19:11 2008''

Revision as of 15:19, 30 June 2008

Image:1b5n.png

Template:STRUCTURE 1b5n

NMR STRUCTURE OF PSP1, PLASMATOCYTE-SPREADING PEPTIDE FROM PSEUDOPLUSIA INCLUDENS

Template:ABSTRACT PUBMED 9988679

About this Structure

1B5N is a Single protein structure. Full experimental information is available from OCA.

Reference

Structure of the insect cytokine peptide plasmatocyte-spreading peptide 1 from Pseudoplusia includens., Volkman BF, Anderson ME, Clark KD, Hayakawa Y, Strand MR, Markley JL, J Biol Chem. 1999 Feb 19;274(8):4493-6. PMID:9988679

Page seeded by OCA on Mon Jun 30 18:19:11 2008

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