1b5t

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{{Seed}}
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{{STRUCTURE_1b5t| PDB=1b5t | SCENE= }}
{{STRUCTURE_1b5t| PDB=1b5t | SCENE= }}
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'''ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE'''
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===ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE===
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==Overview==
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Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in humans. Folate treatment decreases homocysteine levels and dramatically reduces the incidence of neural tube defects. The flavoprotein methylenetetrahydrofolate reductase (MTHFR) is a likely target for these actions of folate. The most common genetic cause of mildly elevated plasma homocysteine in humans is the MTHFR polymorphism A222V (base change C677--&gt;T). The X-ray analysis of E. coli MTHFR, reported here, provides a model for the catalytic domain that is shared by all MTHFRs. This domain is a beta8alpha8 barrel that binds FAD in a novel fashion. Ala 177, corresponding to Ala 222 in human MTHFR, is near the bottom of the barrel and distant from the FAD. The mutation A177V does not affect Km or k(cat) but instead increases the propensity for bacterial MTHFR to lose its essential flavin cofactor. Folate derivatives protect wild-type and mutant E. coli enzymes against flavin loss, and protect human MTHFR and the A222V mutant against thermal inactivation, suggesting a mechanism by which folate treatment reduces homocysteine levels.
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(as it appears on PubMed at http://www.pubmed.gov), where 10201405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10201405}}
==About this Structure==
==About this Structure==
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[[Category: Beta alpha barrel]]
[[Category: Beta alpha barrel]]
[[Category: Reductase]]
[[Category: Reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:06:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:19:53 2008''

Revision as of 15:19, 30 June 2008

Image:1b5t.png

Template:STRUCTURE 1b5t

ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE

Template:ABSTRACT PUBMED 10201405

About this Structure

1B5T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia., Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML, Nat Struct Biol. 1999 Apr;6(4):359-65. PMID:10201405

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