1b6b

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[[Image:1b6b.gif|left|200px]]
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{{Seed}}
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[[Image:1b6b.png|left|200px]]
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{{STRUCTURE_1b6b| PDB=1b6b | SCENE= }}
{{STRUCTURE_1b6b| PDB=1b6b | SCENE= }}
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'''MELATONIN BIOSYNTHESIS: THE STRUCTURE OF SEROTONIN N-ACETYLTRANSFERASE AT 2.5 A RESOLUTION SUGGESTS A CATALYTIC MECHANISM'''
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===MELATONIN BIOSYNTHESIS: THE STRUCTURE OF SEROTONIN N-ACETYLTRANSFERASE AT 2.5 A RESOLUTION SUGGESTS A CATALYTIC MECHANISM===
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==Overview==
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Conversion of serotonin to N-acetylserotonin, the precursor of the circadian neurohormone melatonin, is catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acetyl coenzyme A (AcCoA). AANAT is a globular protein consisting of an eight-stranded beta sheet flanked by five alpha helices; a conserved motif in the center of the beta sheet forms the cofactor binding site. Three polypeptide loops converge above the AcCoA binding site, creating a hydrophobic funnel leading toward the cofactor and serotonin binding sites in the protein interior. Two conserved histidines not found in other NATs are located at the bottom of the funnel in the active site, suggesting a catalytic mechanism for acetylation involving imidazole groups acting as general acid/base catalysts.
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The line below this paragraph, {{ABSTRACT_PUBMED_10024876}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10024876 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10024876}}
==About this Structure==
==About this Structure==
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[[Category: Klein, D C.]]
[[Category: Klein, D C.]]
[[Category: Acetyltransferase]]
[[Category: Acetyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:07:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:22:07 2008''

Revision as of 15:22, 30 June 2008

Image:1b6b.png

Template:STRUCTURE 1b6b

MELATONIN BIOSYNTHESIS: THE STRUCTURE OF SEROTONIN N-ACETYLTRANSFERASE AT 2.5 A RESOLUTION SUGGESTS A CATALYTIC MECHANISM

Template:ABSTRACT PUBMED 10024876

About this Structure

1B6B is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism., Hickman AB, Klein DC, Dyda F, Mol Cell. 1999 Jan;3(1):23-32. PMID:10024876

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