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| - | [[Image:1b6u.jpg|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1b6u| PDB=1b6u | SCENE= }} | | {{STRUCTURE_1b6u| PDB=1b6u | SCENE= }} |
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| - | '''CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES'''
| + | ===CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES=== |
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| - | ==Overview==
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| - | BACKGROUND: T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify infected cells directly through recognition of antigenic peptides that are displayed at the target cell surface by the classical major histocompatibility complex (MHC) class I molecules. NK cells monitor the target cell surface for malfunction of this display system, lysing potentially infected cells that might otherwise evade recognition by the T cells. Human killer cell inhibitory receptors (KIRs) control this process by either inhibiting or activating the cytotoxic activity of NK cells via specific binding to MHC class I molecules on the target cell. RESULTS: We report the crystal structure of the extracellular region of the human p58 KIR (KIR2DL3), which is specific for the human MHC class I molecule HLA-Cw3 and related alleles. The structure shows the predicted topology of two tandem immunoglobulin-like domains, but comparison with the previously reported structure of the related receptor KIR2DL1 reveals an unexpected change of 23 degrees in the relative orientation of these domains. CONCLUSIONS: The altered orientation of the immunoglobulin-like domains maintains an unusually acute interdomain elbow angle, which therefore appears to be a distinctive feature of the KIRs. The putative MHC class I binding site is located on the outer surface of the elbow, spanning both domains. The unexpected observation that this binding site can be modulated by differences in the relative domain orientations has implications for the general mechanism of KIR-MHC class I complex formation.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_10196125}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 10196125 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_10196125}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Killer cell inhibitory receptor]] | | [[Category: Killer cell inhibitory receptor]] |
| | [[Category: Natural killer cell]] | | [[Category: Natural killer cell]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:08:39 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:24:13 2008'' |
Revision as of 15:24, 30 June 2008
Template:STRUCTURE 1b6u
CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES
Template:ABSTRACT PUBMED 10196125
About this Structure
1B6U is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I., Maenaka K, Juji T, Stuart DI, Jones EY, Structure. 1999 Apr 15;7(4):391-8. PMID:10196125
Page seeded by OCA on Mon Jun 30 18:24:13 2008
