2kve

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<StructureSection load='2kve' size='340' side='right'caption='[[2kve]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2kve' size='340' side='right'caption='[[2kve]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2KVE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kvd|2kvd]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kvd|2kvd]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2kve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kve OCA], [http://pdbe.org/2kve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kve RCSB], [http://www.ebi.ac.uk/pdbsum/2kve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kve ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kve OCA], [https://pdbe.org/2kve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kve RCSB], [https://www.ebi.ac.uk/pdbsum/2kve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kve ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma.
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[[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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[[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 07:36, 2 February 2022

C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)

PDB ID 2kve

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