5ex4

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Current revision (08:31, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5ex4' size='340' side='right'caption='[[5ex4]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5ex4' size='340' side='right'caption='[[5ex4]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ex4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EX4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ex4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EX4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e5g|5e5g]], [[3nue|3nue]], [[3rzi|3rzi]], [[3kgf|3kgf]], [[2ypo|2ypo]], [[2ypp|2ypp]], [[2ypq|2ypq]], [[5e2l|5e2l]], [[5e40|5e40]], [[5e4n|5e4n]], [[5e7z|5e7z]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroG_1, ERS024751_03564, ERS094182_00944, ERS124362_02783 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ex4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex4 OCA], [https://pdbe.org/5ex4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ex4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ex4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ex4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ex4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex4 OCA], [http://pdbe.org/5ex4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ex4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ex4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ex4 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AROG_MYCTU AROG_MYCTU] Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.<ref>PMID:16288916</ref>
==See Also==
==See Also==
*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blackmore, N J]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Hutton, R D]]
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[[Category: Blackmore NJ]]
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[[Category: Jiao, W]]
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[[Category: Hutton RD]]
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[[Category: Parker, E J]]
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[[Category: Jiao W]]
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[[Category: Reichau, S]]
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[[Category: Parker EJ]]
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[[Category: Allosteric regulation]]
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[[Category: Reichau S]]
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[[Category: Shikimate pathway]]
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[[Category: Transferase]]
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Current revision

3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with tryptophan in all three allosteric binding sites

PDB ID 5ex4

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OCA

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