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5exo

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Current revision (08:31, 12 July 2023) (edit) (undo)
 
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<StructureSection load='5exo' size='340' side='right'caption='[[5exo]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='5exo' size='340' side='right'caption='[[5exo]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5exo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EXO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EXO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5exo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EXO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5SY:[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(HYDROXYMETHYL)-2-METHOXY-5-OXIDANYL-4-[(2-OXIDANYLIDENECHROMEN-3-YL)METHOXY]OXAN-3-YL]+ETHANOATE'>5SY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.502&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5SY:[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(HYDROXYMETHYL)-2-METHOXY-5-OXIDANYL-4-[(2-OXIDANYLIDENECHROMEN-3-YL)METHOXY]OXAN-3-YL]+ETHANOATE'>5SY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5exo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5exo OCA], [http://pdbe.org/5exo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5exo RCSB], [http://www.ebi.ac.uk/pdbsum/5exo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5exo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5exo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5exo OCA], [https://pdbe.org/5exo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5exo RCSB], [https://www.ebi.ac.uk/pdbsum/5exo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5exo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blanchard, H]]
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[[Category: Blanchard H]]
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[[Category: Collins, P M]]
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[[Category: Collins PM]]
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[[Category: Beta sandwich]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Carbohydrate-recognition]]
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[[Category: Coumaryl]]
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[[Category: Inhibitor]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of Human galectin-3 CRD in complex with methyl 2-O-acetyl-3-O-(2H-chromene-3-yl-methyl)-a-D-galactopyranoside inhibitor

PDB ID 5exo

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OCA

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