1b77

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[[Image:1b77.gif|left|200px]]
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{{Seed}}
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[[Image:1b77.png|left|200px]]
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{{STRUCTURE_1b77| PDB=1b77 | SCENE= }}
{{STRUCTURE_1b77| PDB=1b77 | SCENE= }}
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'''BUILDING A REPLISOME STRUCTURE FROM INTERACTING PIECES: A SLIDING CLAMP COMPLEXED WITH AN INTERACTION PEPTIDE FROM DNA POLYMERASE'''
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===BUILDING A REPLISOME STRUCTURE FROM INTERACTING PIECES: A SLIDING CLAMP COMPLEXED WITH AN INTERACTION PEPTIDE FROM DNA POLYMERASE===
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==Overview==
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We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA polymerase interactions, and the DNA polymerase complexed with primer-template DNA. The editing complex structure shows a partially melted duplex DNA exiting from the exonuclease domain at an unexpected angle and significant changes in the protein structure. The clamp complex shows the C-terminal 11 residues of polymerase bound in a hydrophobic pocket, and it allows docking of the editing and clamp structures together. The peptide binds to the sliding clamp at a position identical to that of a replication inhibitor peptide bound to PCNA, suggesting that the replication inhibitor protein p21CIP1 functions by competing with eukaryotic polymerases for the same binding pocket on the clamp.
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The line below this paragraph, {{ABSTRACT_PUBMED_10535734}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10535734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10535734}}
==About this Structure==
==About this Structure==
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[[Category: Replisome]]
[[Category: Replisome]]
[[Category: Sliding clamp]]
[[Category: Sliding clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:09:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:26:08 2008''

Revision as of 15:26, 30 June 2008

Image:1b77.png

Template:STRUCTURE 1b77

BUILDING A REPLISOME STRUCTURE FROM INTERACTING PIECES: A SLIDING CLAMP COMPLEXED WITH AN INTERACTION PEPTIDE FROM DNA POLYMERASE

Template:ABSTRACT PUBMED 10535734

About this Structure

1B77 is a Single protein structure of sequence from Enterobacteria phage rb69. Full crystallographic information is available from OCA.

Reference

Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex., Shamoo Y, Steitz TA, Cell. 1999 Oct 15;99(2):155-66. PMID:10535734

Page seeded by OCA on Mon Jun 30 18:26:08 2008

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