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5fai

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EMG1 N1-Specific Pseudouridine Methyltransferase

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Retrieved from "http://52.214.119.220/wiki/index.php/5fai"

@@ Line 3: / Line 3: @@
 <StructureSection load='5fai' size='340' side='right'caption='[[5fai]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FAI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FAI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EMG1, C2F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [http://pdbe.org/5fai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [http://www.ebi.ac.uk/pdbsum/5fai PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fai ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [https://pdbe.org/5fai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [https://www.ebi.ac.uk/pdbsum/5fai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fai ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref>
+[https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: BROWN, P J]]
+[[Category: BROWN PJ]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: DONG, A]]
+[[Category: DONG A]]
-[[Category: Edwards, A M]]
+[[Category: Edwards AM]]
-[[Category: LI, Y]]
+[[Category: LI Y]]
-[[Category: Structural genomic]]
+[[Category: TEMPEL W]]
-[[Category: TEMPEL, W]]
+[[Category: WU H]]
-[[Category: WU, H]]
+[[Category: ZENG H]]
-[[Category: ZENG, H]]
-[[Category: Emg1]]
-[[Category: Methyltransferase]]
-[[Category: Sgc]]
-[[Category: Transferase]]

5fai

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EMG1 N1-Specific Pseudouridine Methyltransferase

Structural highlights

Disease

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