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1b7g

From Proteopedia

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[[Image:1b7g.jpg|left|200px]]
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{{Seed}}
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[[Image:1b7g.png|left|200px]]
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{{STRUCTURE_1b7g| PDB=1b7g | SCENE= }}
{{STRUCTURE_1b7g| PDB=1b7g | SCENE= }}
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'''GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE'''
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===GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE===
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==Overview==
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The enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the archaea shows low sequence identity (16-20%) with its eubacterial and eukaryotic counterparts. The crystal structure of the apo GAPDH from Sulfolobus solfataricus has been determined by multiple isomorphous replacement at 2.05 A resolution. The enzyme has several differences in secondary structure when compared with eubacterial GAPDHs, with an overall increase in the number of alpha-helices. There is a relocation of the active-site residues within the catalytic domain of the enzyme. The thermostability of the S. solfataricus enzyme can be attributed to a combination of an ion pair cluster and an intrasubunit disulphide bond.
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(as it appears on PubMed at http://www.pubmed.gov), where 10448043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10448043}}
==About this Structure==
==About this Structure==
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[[Category: Hyperthermophile]]
[[Category: Hyperthermophile]]
[[Category: Hyperthermophilic dehydrogenase]]
[[Category: Hyperthermophilic dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:10:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:27:03 2008''

Revision as of 15:27, 30 June 2008

Image:1b7g.png

Template:STRUCTURE 1b7g

GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE

Template:ABSTRACT PUBMED 10448043

About this Structure

1B7G is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus., Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA, J Mol Biol. 1999 Aug 20;291(3):651-60. PMID:10448043

Page seeded by OCA on Mon Jun 30 18:27:03 2008

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