General secretion pathway protein
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
'''General secretion pathway proteins''' (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via '''type II secretion system''' or T2SS. Examples are the transport of cholera toxin by ''Vibrio cholerae'' and exotoxin A by ''Pseudomonas aeruginosa''<ref>PMID:26999395</ref>. In ''Pseudomonas aeruginosa'' the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See [[Pseudopilin]]. | '''General secretion pathway proteins''' (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via '''type II secretion system''' or T2SS. Examples are the transport of cholera toxin by ''Vibrio cholerae'' and exotoxin A by ''Pseudomonas aeruginosa''<ref>PMID:26999395</ref>. In ''Pseudomonas aeruginosa'' the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See [[Pseudopilin]]. | ||
| - | |||
| - | == Disease == | ||
| - | |||
| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| + | |||
| + | The 3D structure of the bacterial core shows a 15-fold rotationally symmetric PulD called secretin which inserts into the cell membrane and enables conductance of substrate intothe external environment<ref>PMID:31780649</ref>. | ||
Revision as of 09:32, 1 May 2020
| |||||||||||
3D structures of general secretion pathway protein
Updated on 01-May-2020
References
- ↑ Green ER, Mecsas J. Bacterial Secretion Systems: An Overview. Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0012-2015. PMID:26999395 doi:http://dx.doi.org/10.1128/microbiolspec.VMBF-0012-2015
- ↑ Chernyatina AA, Low HH. Core architecture of a bacterial type II secretion system. Nat Commun. 2019 Nov 28;10(1):5437. doi: 10.1038/s41467-019-13301-3. PMID:31780649 doi:http://dx.doi.org/10.1038/s41467-019-13301-3
