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1b89

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[[Image:1b89.gif|left|200px]]
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[[Image:1b89.png|left|200px]]
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==Overview==
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{{ABSTRACT_10360576}}
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Clathrin is a triskelion-shaped cytoplasmic protein that polymerizes into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of membrane proteins during endocytosis and organelle biogenesis by interacting with membrane-associated adaptor molecules. The clathrin triskelion is a trimer of heavy-chain subunits (1,675 residues), each binding a single light-chain subunit, in the hub domain (residues 1,074-1,675). Light chains negatively modulate polymerization so that intracellular clathrin assembly is adaptor-dependent. Here we report the atomic structure, to 2.6 A resolution, of hub residues 1,210-1,516 involved in mediating spontaneous clathrin heavy-chain polymerization and light-chain association. The hub fragment folds into an elongated coil of alpha-helices, and alignment analyses reveal a 145-residue motif that is repeated seven times along the filamentous leg and appears in other proteins involved in vacuolar protein sorting. The resulting model provides a three-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding and trimerization.
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==About this Structure==
==About this Structure==
1B89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The following page contains interesting information on the relation of 1B89 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B89 OCA].
1B89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The following page contains interesting information on the relation of 1B89 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb88_1.html Clathrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B89 OCA].
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==Reference==
 
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Clathrin self-assembly is mediated by a tandemly repeated superhelix., Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK, Nature. 1999 May 27;399(6734):371-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360576 10360576]
 
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Clathrin]]
[[Category: Clathrin]]
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[[Category: Self-assembly]]
[[Category: Self-assembly]]
[[Category: Triskelion]]
[[Category: Triskelion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:11:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:04:09 2008''

Revision as of 14:04, 26 June 2008

Image:1b89.png

Template:STRUCTURE 1b89

CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)


Template:ABSTRACT 10360576

About this Structure

1B89 is a Single protein structure of sequence from Bos taurus. The following page contains interesting information on the relation of 1B89 with [Clathrin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:04:09 2008

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