6yv4
From Proteopedia
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| - | ==STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT | + | ==STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686== |
| - | <StructureSection load='6yv4' size='340' side='right'caption='[[6yv4]]' scene=''> | + | <StructureSection load='6yv4' size='340' side='right'caption='[[6yv4]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YV4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6yv4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YV4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yv4 OCA], [http://pdbe.org/6yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/6yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yv4 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PQK:1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic+acid'>PQK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOTUM, OK/SW-CL.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Wnt_protein]_O-palmitoleoyl-L-serine_hydrolase [Wnt protein] O-palmitoleoyl-L-serine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.98 3.1.1.98] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yv4 OCA], [http://pdbe.org/6yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/6yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yv4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOTUM_HUMAN NOTUM_HUMAN]] May deacetylate GlcNAc residues on cell surface glycans. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hillier J]] | + | [[Category: Hillier, J]] |
| - | [[Category: Jones | + | [[Category: Jones, E Y]] |
| - | [[Category: Ruza | + | [[Category: Ruza, R R]] |
| + | [[Category: Fragment screen]] | ||
| + | [[Category: Frizzled]] | ||
| + | [[Category: Fzd]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Notum]] | ||
| + | [[Category: Wnt]] | ||
| + | [[Category: Wnt signalling]] | ||
Revision as of 06:43, 3 June 2020
STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686
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Categories: Human | Large Structures | Hillier, J | Jones, E Y | Ruza, R R | Fragment screen | Frizzled | Fzd | Hydrolase | Notum | Wnt | Wnt signalling
