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| | <StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution|resolution]] 2.60Å' scene=''> | | <StructureSection load='6d69' size='340' side='right'caption='[[6d69]], [[Resolution|resolution]] 2.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6d69]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D69 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6d69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D69 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tn, abba, CG15105, Dmel_CG15105 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [http://pdbe.org/6d69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [http://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d69 OCA], [https://pdbe.org/6d69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d69 RCSB], [https://www.ebi.ac.uk/pdbsum/6d69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d69 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q7JUV6_DROME Q7JUV6_DROME] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Drome]] | + | [[Category: Drosophila melanogaster]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Geisbrecht, B V]] | + | [[Category: Geisbrecht BV]] |
| - | [[Category: McWhorter, W J]] | + | [[Category: McWhorter WJ]] |
| - | [[Category: Ramyar, K X]] | + | [[Category: Ramyar KX]] |
| - | [[Category: Beta-propeller]]
| + | |
| - | [[Category: Limb girdle muscular dystrophy type 2h]]
| + | |
| - | [[Category: Protein binding]]
| + | |
| - | [[Category: Protein-protein interaction]]
| + | |
| Structural highlights
Function
Q7JUV6_DROME
Publication Abstract from PubMed
Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactions with the glycolytic enzymes Aldolase and Phosphoglycerate mutase. Loss of Drosophila TRIM32, encoded by thin (tn), shows reduced levels of glycolytic intermediates and amino acids. This altered metabolic profile correlates with a reduction in the size of glycolytic larval muscle and brain tissue. Consistent with a role for metabolic intermediates in glycolysis-driven biomass production, dietary amino acid supplementation in tn mutants improves muscle mass. Remarkably, TRIM32 is also required for ectopic growth - loss of TRIM32 in a wing disc-associated tumor model reduces glycolytic metabolism and restricts growth. Overall, our results reveal a novel role for TRIM32 for controlling glycolysis in the context of both normal development and tumor growth.
Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.,Bawa S, Brooks DS, Neville KE, Tipping M, Sagar MA, Kollhoff JA, Chawla G, Geisbrecht BV, Tennessen JM, Eliceiri KW, Geisbrecht ER Elife. 2020 Mar 30;9. pii: 52358. doi: 10.7554/eLife.52358. PMID:32223900[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Bawa S, Brooks DS, Neville KE, Tipping M, Sagar MA, Kollhoff JA, Chawla G, Geisbrecht BV, Tennessen JM, Eliceiri KW, Geisbrecht ER. Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth. Elife. 2020 Mar 30;9. pii: 52358. doi: 10.7554/eLife.52358. PMID:32223900 doi:http://dx.doi.org/10.7554/eLife.52358
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