1b8q

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[[Image:1b8q.gif|left|200px]]
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{{Seed}}
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[[Image:1b8q.png|left|200px]]
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{{STRUCTURE_1b8q| PDB=1b8q | SCENE= }}
{{STRUCTURE_1b8q| PDB=1b8q | SCENE= }}
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'''SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE'''
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===SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE===
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==Overview==
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The PDZ domain of neuronal nitric oxide synthase (nNOS) functions as a scaffold for organizing the signal transduction complex of the enzyme. The NMR structure of a complex composed of the nNOS PDZ domain and an associated peptide suggests that a two-stranded beta-sheet C-terminal to the canonical PDZ domain may mediate its interaction with the PDZ domains of postsynaptic density-95 and alpha-syntrophin. The structure also provides the molecular basis of recognition of Asp-X-Val-COOH peptides by the nNOS PDZ domain. The role of the C-terminal extension in Asp-X-Val-COOH peptide binding is investigated. Additionally, NMR studies further show that the Asp-X-Val-COOH peptide and a C-terminal peptide from a novel cytosolic protein named CAPON bind to the same pocket of the nNOS PDZ domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_10331866}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10331866 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10331866}}
==About this Structure==
==About this Structure==
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1B8Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].
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1B8Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8Q OCA].
==Reference==
==Reference==
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[[Category: Nno]]
[[Category: Nno]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:12:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:34:35 2008''

Revision as of 15:34, 30 June 2008

Image:1b8q.png

Template:STRUCTURE 1b8q

SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE

Template:ABSTRACT PUBMED 10331866

About this Structure

1B8Q is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide., Tochio H, Zhang Q, Mandal P, Li M, Zhang M, Nat Struct Biol. 1999 May;6(5):417-21. PMID:10331866

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