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| | <StructureSection load='6rgv' size='340' side='right'caption='[[6rgv]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='6rgv' size='340' side='right'caption='[[6rgv]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6rgv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salts Salts]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RGV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6rgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._SL1344 Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RGV FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1io1|1io1]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fljB, SL1344_2756 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216597 SALTS])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgv OCA], [https://pdbe.org/6rgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rgv RCSB], [https://www.ebi.ac.uk/pdbsum/6rgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgv ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgv OCA], [http://pdbe.org/6rgv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rgv RCSB], [http://www.ebi.ac.uk/pdbsum/6rgv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgv ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/A0A0H3NEZ8_SALTS A0A0H3NEZ8_SALTS]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.[RuleBase:RU362073] | + | [https://www.uniprot.org/uniprot/FLJB_SALTY FLJB_SALTY] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. |
| - | <div style="background-color:#fffaf0;">
| + | |
| - | == Publication Abstract from PubMed ==
| + | |
| - | The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and FljB, are methylated at surface-exposed lysine residues by FliB. A Salmonella Typhimurium mutant deficient in flagellin methylation is outcompeted for gut colonization in a gastroenteritis mouse model, and methylation of flagellin promotes bacterial invasion of epithelial cells in vitro. Lysine methylation increases the surface hydrophobicity of flagellin, and enhances flagella-dependent adhesion of Salmonella to phosphatidylcholine vesicles and epithelial cells. Therefore, posttranslational methylation of flagellin facilitates adhesion of Salmonella Typhimurium to hydrophobic host cell surfaces, and contributes to efficient gut colonization and host infection.
| + | |
| | | | |
| - | Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.,Horstmann JA, Lunelli M, Cazzola H, Heidemann J, Kuhne C, Steffen P, Szefs S, Rossi C, Lokareddy RK, Wang C, Lemaire L, Hughes KT, Uetrecht C, Schluter H, Grassl GA, Stradal TEB, Rossez Y, Kolbe M, Erhardt M Nat Commun. 2020 Apr 24;11(1):2013. doi: 10.1038/s41467-020-15738-3. PMID:32332720<ref>PMID:32332720</ref>
| + | ==See Also== |
| - | | + | *[[Flagellin 3D structures|Flagellin 3D structures]] |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 6rgv" style="background-color:#fffaf0;"></div>
| + | |
| - | == References == | + | |
| - | <references/>
| + | |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Salts]] | + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]] |
| - | [[Category: Kolbe, M]] | + | [[Category: Kolbe M]] |
| - | [[Category: Lokareddy, R K]] | + | [[Category: Lokareddy RK]] |
| - | [[Category: Lunelli, M]] | + | [[Category: Lunelli M]] |
| - | [[Category: Bacterial motility]]
| + | |
| - | [[Category: Cell adhesion]]
| + | |
| - | [[Category: Flagellum]]
| + | |
| - | [[Category: Methylation]]
| + | |
| - | [[Category: Structural protein]]
| + | |
