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1b8w

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[[Image:1b8w.jpg|left|200px]]
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{{STRUCTURE_1b8w| PDB=1b8w | SCENE= }}
{{STRUCTURE_1b8w| PDB=1b8w | SCENE= }}
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'''DEFENSIN-LIKE PEPTIDE 1'''
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===DEFENSIN-LIKE PEPTIDE 1===
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==Overview==
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Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.
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{{ABSTRACT_PUBMED_10417345}}
==About this Structure==
==About this Structure==
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1B8W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].
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1B8W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].
==Reference==
==Reference==
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[[Category: Platypus]]
[[Category: Platypus]]
[[Category: Toxin]]
[[Category: Toxin]]
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Revision as of 15:35, 30 June 2008

Image:1b8w.png

Template:STRUCTURE 1b8w

DEFENSIN-LIKE PEPTIDE 1

Template:ABSTRACT PUBMED 10417345

About this Structure

1B8W is a Single protein structure of sequence from Ornithorhynchus anatinus. Full experimental information is available from OCA.

Reference

Solution structure of a defensin-like peptide from platypus venom., Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW, Biochem J. 1999 Aug 1;341 ( Pt 3):785-94. PMID:10417345

Page seeded by OCA on Mon Jun 30 18:35:24 2008

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