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2l73

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<StructureSection load='2l73' size='340' side='right'caption='[[2l73]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
<StructureSection load='2l73' size='340' side='right'caption='[[2l73]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [http://pdbe.org/2l73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [http://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [https://pdbe.org/2l73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [https://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN]] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref>
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[[https://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN]] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref>
== References ==
== References ==
<references/>
<references/>

Revision as of 07:49, 9 February 2022

Structure of the NOXO1b PX domain

PDB ID 2l73

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