2lcm

<table><tr><td colspan='2'>[[2lcm]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LCM FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lcm OCA], [http://pdbe.org/2lcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lcm RCSB], [http://www.ebi.ac.uk/pdbsum/2lcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lcm ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CAC1B_HUMAN CAC1B_HUMAN]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.