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1b9m

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{{STRUCTURE_1b9m| PDB=1b9m | SCENE= }}
{{STRUCTURE_1b9m| PDB=1b9m | SCENE= }}
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'''REGULATOR FROM ESCHERICHIA COLI'''
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===REGULATOR FROM ESCHERICHIA COLI===
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==Overview==
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The molybdate-dependent transcriptional regulator (ModE) from Escherichia coli functions as a sensor of molybdate concentration and a regulator for transcription of operons involved in the uptake and utilization of the essential element, molybdenum. We have determined the structure of ModE using multi-wavelength anomalous dispersion. Selenomethionyl and native ModE models are refined to 1. 75 and 2.1 A, respectively and describe the architecture and structural detail of a complete transcriptional regulator. ModE is a homodimer and each subunit comprises N- and C-terminal domains. The N-terminal domain carries a winged helix-turn-helix motif for binding to DNA and is primarily responsible for ModE dimerization. The C-terminal domain contains the molybdate-binding site and residues implicated in binding the oxyanion are identified. This domain is divided into sub-domains a and b which have similar folds, although the organization of secondary structure elements varies. The sub-domain fold is related to the oligomer binding-fold and similar to that of the subunits of several toxins which are involved in extensive protein-protein interactions. This suggests a role for the C-terminal domain in the formation of the ModE-protein-DNA complexes necessary to regulate transcription. Modelling of ModE interacting with DNA suggests that a large distortion of DNA is not necessary for complex formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 10075916 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10075916}}
==About this Structure==
==About this Structure==
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[[Category: Ob fold]]
[[Category: Ob fold]]
[[Category: Winged helix turn helix]]
[[Category: Winged helix turn helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:14:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:38:37 2008''

Revision as of 15:38, 30 June 2008

Image:1b9m.png

Template:STRUCTURE 1b9m

REGULATOR FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 10075916

About this Structure

1B9M is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds., Hall DR, Gourley DG, Leonard GA, Duke EM, Anderson LA, Boxer DH, Hunter WN, EMBO J. 1999 Mar 15;18(6):1435-46. PMID:10075916

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