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1ba2

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{{STRUCTURE_1ba2| PDB=1ba2 | SCENE= }}
{{STRUCTURE_1ba2| PDB=1ba2 | SCENE= }}
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'''D67R MUTANT OF D-RIBOSE-BINDING PROTEIN FROM ESCHERICHIA COLI'''
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===D67R MUTANT OF D-RIBOSE-BINDING PROTEIN FROM ESCHERICHIA COLI===
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==Overview==
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Conformational changes are necessary for the function of bacterial periplasmic receptors in chemotaxis and transport. Such changes allow entry and exit of ligand, and enable the correct interaction of the ligand-bound proteins with the membrane components of each system. Three open, ligand-free forms of the Escherichia coli ribose-binding protein were observed here by X-ray crystallographic studies. They are opened by 43 degrees, 50 degrees and 64 degrees with respect to the ligand-bound protein reported previously. The three open forms are not distinct, but show a clear relationship to each other. All are the product of a similar opening motion, and are stabilized by a new, almost identical packing interface between the domains. The changes are generated by similar bond rotations, although some differences in the three hinge segments are needed to accommodate the various structural scenarios. Some local repacking also occurs as interdomain contacts are lost. The least open (43 degrees) form is probably the dominant one in solution under normal conditions, although a mixture of species seems likely. The open and closed forms have distinct surfaces in the regions known to be important in chemotaxis and transport, which will differentiate their interactions with the membrane components. It seems certain that the conformational path that links the forms described here is that followed during ligand retrieval, and in ligand release into the membrane-bound permease system.
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(as it appears on PubMed at http://www.pubmed.gov), where 9641984 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9641984}}
==About this Structure==
==About this Structure==
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[[Category: Periplasm]]
[[Category: Periplasm]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:15:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:40:37 2008''

Revision as of 15:40, 30 June 2008

Image:1ba2.png

Template:STRUCTURE 1ba2

D67R MUTANT OF D-RIBOSE-BINDING PROTEIN FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 9641984

About this Structure

1BA2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Multiple open forms of ribose-binding protein trace the path of its conformational change., Bjorkman AJ, Mowbray SL, J Mol Biol. 1998 Jun 12;279(3):651-64. PMID:9641984

Page seeded by OCA on Mon Jun 30 18:40:37 2008

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