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1ba5

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{{STRUCTURE_1ba5| PDB=1ba5 | SCENE= }}
{{STRUCTURE_1ba5| PDB=1ba5 | SCENE= }}
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'''DNA-BINDING DOMAIN OF HUMAN TELOMERIC PROTEIN, HTRF1, NMR, 18 STRUCTURES'''
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===DNA-BINDING DOMAIN OF HUMAN TELOMERIC PROTEIN, HTRF1, NMR, 18 STRUCTURES===
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==Overview==
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BACKGROUND: Mammalian telomeres consist of long tandem arrays of the double-stranded TTAGGG sequence motif packaged by a telomere repeat binding factor, TRF1. The DNA-binding domain of TRF1 shows sequence homology to each of three tandem repeats of the DNA-binding domain of the transcriptional activator c-Myb. The isolated c-Myb-like domain of human TRF1 (hTRF1) binds specifically to telomeric DNA as a monomer, in a similar manner to that of homeodomains. So far, the only three-dimensional structure of a telomeric protein to be determined is that of a yeast telomeric protein, Rap 1p. The DNA-binding domain of Rap 1p contains two subdomains that are structurally closely related to c-Myb repeats. We set out to determine the solution structure of the DNA-binding domain of hTRF1 in order to establish its mode of DNA binding. RESULTS: The solution structure of the DNA-binding domain of hTRF1 has been determined and shown to comprise three helices. The architecture of the three helices is very similar to that of each Rap 1p subdomain and also to that of each c-Myb repeat. The second and third helix form a helix-turn-helix (HTH) variant. The length of the third helix of hTRF1 is similar to that of the second subdomain of Rap 1p. CONCLUSIONS: The hTRF1 DNA-binding domain is likely to bind to DNA in a similar manner to that of the second subdomain of Rap 1p. On the basis of the Rap 1p-DNA complex, a model of the hTRF1 DNA-binding domain in complex with human telomeric DNA was constructed. In addition to DNA recognition by the HTH variant, a flexible N-terminal arm of hTRF1 is likely to interact with DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 9739097 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9739097}}
==About this Structure==
==About this Structure==
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1BA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BA5 OCA].
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1BA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BA5 OCA].
==Reference==
==Reference==
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[[Category: Telomere]]
[[Category: Telomere]]
[[Category: Trf]]
[[Category: Trf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:16:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:41:06 2008''

Revision as of 15:41, 30 June 2008

Image:1ba5.png

Template:STRUCTURE 1ba5

DNA-BINDING DOMAIN OF HUMAN TELOMERIC PROTEIN, HTRF1, NMR, 18 STRUCTURES

Template:ABSTRACT PUBMED 9739097

About this Structure

1BA5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the DNA-binding domain of human telomeric protein, hTRF1., Nishikawa T, Nagadoi A, Yoshimura S, Aimoto S, Nishimura Y, Structure. 1998 Aug 15;6(8):1057-65. PMID:9739097

Page seeded by OCA on Mon Jun 30 18:41:06 2008

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