6rbi

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Current revision (12:18, 24 January 2024) (edit) (undo)
 
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==Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol==
==Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol==
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<StructureSection load='6rbi' size='340' side='right'caption='[[6rbi]]' scene=''>
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<StructureSection load='6rbi' size='340' side='right'caption='[[6rbi]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RBI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RBI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RBI FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rbi OCA], [http://pdbe.org/6rbi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rbi RCSB], [http://www.ebi.ac.uk/pdbsum/6rbi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rbi ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JX8:5-(1~{H}-1,2,3,4-tetrazol-5-yl)quinolin-8-ol'>JX8</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rbi OCA], [https://pdbe.org/6rbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rbi RCSB], [https://www.ebi.ac.uk/pdbsum/6rbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rbi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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==See Also==
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith CH]]

Current revision

Crystal structure of KDM5B in complex with 5-(1H-tetrazol-5-yl)quinolin-8-ol

PDB ID 6rbi

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