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1bau

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{{STRUCTURE_1bau| PDB=1bau | SCENE= }}
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'''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''
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===NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.
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The line below this paragraph, {{ABSTRACT_PUBMED_9628479}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9628479 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9628479}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:17:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:43:40 2008''

Revision as of 15:43, 30 June 2008

Image:1bau.png

Template:STRUCTURE 1bau

NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9628479

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479

Page seeded by OCA on Mon Jun 30 18:43:40 2008

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