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2lvv

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Revision as of 11:30, 16 February 2022

NMR structure of TB24

Structural highlights

2lvv is a 1 chain structure with sequence from Trybb. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FCA2_TRYBB] May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

Publication Abstract from PubMed

Flagellar calcium binding proteins are expressed in a variety of trypanosomes and are potential drug targets for Chagas disease and African sleeping sickness. The flagellar calcium binding protein calflagin of Trypanosoma brucei (called Tb24) is a myristoylated and palmitoylated EF-hand protein that is targeted to the inner leaflet of the flagellar membrane. The Tb24 protein may also interact with proteins on the membrane surface that may be different from those bound to flagellar calcium binding proteins (FCaBPs) in T. cruzi. We report here the NMR structure of Tb24 that contains four EF-hand motifs bundled in a compact arrangement, similar to the overall fold of T. cruzi FCaBP (RMSD = 1.0 A). A cluster of basic residues (K22, K25, K31, R36, and R38) located on a surface near the N-terminal myristoyl group may be important for membrane binding. Non-conserved residues on the surface of a hydrophobic groove formed by EF2 (P91, Q95, D103, and V108) and EF4 (C194, T198, K199, Q202, and V203) may serve as a target protein binding site and could have implications for membrane target recognition.

NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.,Xu X, Olson CL, Engman DM, Ames JB Protein Sci. 2012 Sep 25. doi: 10.1002/pro.2167. PMID:23011904^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Xu X, Olson CL, Engman DM, Ames JB. NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei. Protein Sci. 2012 Sep 25. doi: 10.1002/pro.2167. PMID:23011904 doi:http://dx.doi.org/10.1002/pro.2167

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lvv"

Categories: Large Structures | Trybb | Ames, J | Ef-hand | Metal binding protein

@@ Line 3: / Line 3: @@
 <StructureSection load='2lvv' size='340' side='right'caption='[[2lvv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2lvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LVV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2lvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2lvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvv OCA], [http://pdbe.org/2lvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lvv RCSB], [http://www.ebi.ac.uk/pdbsum/2lvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvv ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvv OCA], [https://pdbe.org/2lvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvv RCSB], [https://www.ebi.ac.uk/pdbsum/2lvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvv ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FCA2_TRYBB FCA2_TRYBB]] May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.
+[[https://www.uniprot.org/uniprot/FCA2_TRYBB FCA2_TRYBB]] May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

2lvv

From Proteopedia

Revision as of 11:30, 16 February 2022

NMR structure of TB24

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

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