5g6v
From Proteopedia
(Difference between revisions)
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<StructureSection load='5g6v' size='340' side='right'caption='[[5g6v]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='5g6v' size='340' side='right'caption='[[5g6v]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G6V FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [https://pdbe.org/5g6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [https://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref> |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | + | [[Category: Bountra C]] | |
| - | [[Category: Bountra | + | [[Category: Bullock A]] |
| - | [[Category: Bullock | + | [[Category: Burgess-Brown N]] |
| - | [[Category: Burgess-Brown | + | [[Category: Dixon-Clarke SE]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Elkins J]] |
| - | [[Category: | + | [[Category: Galan Bartual S]] |
| - | [[Category: | + | [[Category: Heroven C]] |
| - | [[Category: Heroven | + | [[Category: Kopec J]] |
| - | [[Category: Kopec | + | [[Category: Mackenzie A]] |
| - | [[Category: Mackenzie | + | [[Category: Savitsky P]] |
| - | [[Category: Savitsky | + | [[Category: Tallant C]] |
| - | [[Category: Tallant | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
Revision as of 13:41, 26 July 2023
Crystal structure of the PCTAIRE1 kinase in complex with inhibitor
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