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5gir

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Current revision (11:32, 2 August 2023) (edit) (undo)
 
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<StructureSection load='5gir' size='340' side='right'caption='[[5gir]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='5gir' size='340' side='right'caption='[[5gir]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gir]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GIR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gir]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GIR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gis|5gis]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gir OCA], [https://pdbe.org/5gir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gir RCSB], [https://www.ebi.ac.uk/pdbsum/5gir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gir ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gir OCA], [http://pdbe.org/5gir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gir RCSB], [http://www.ebi.ac.uk/pdbsum/5gir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gir ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
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== Function ==
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[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Kaneko, K K]]
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[[Category: Kaneko KK]]
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[[Category: Kato, Y]]
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[[Category: Kato Y]]
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[[Category: Kitago, Y]]
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[[Category: Kitago Y]]
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[[Category: Ogasawara, S]]
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[[Category: Ogasawara S]]
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[[Category: Takagi, J]]
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[[Category: Takagi J]]
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[[Category: Fab]]
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[[Category: Immune system]]
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[[Category: Mutation]]
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[[Category: Peptide ligand]]
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Current revision

Crystal structure of a Fab fragment with its ligand peptide

PDB ID 5gir

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