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5gqq

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<StructureSection load='5gqq' size='340' side='right'caption='[[5gqq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5gqq' size='340' side='right'caption='[[5gqq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [http://pdbe.org/5gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [http://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [https://pdbe.org/5gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [https://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>
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[https://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Cell death protein|Cell death protein]]
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Feng, Y]]
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[[Category: Feng Y]]
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[[Category: Liu, X]]
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[[Category: Liu X]]
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[[Category: Ma, J]]
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[[Category: Ma J]]
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[[Category: Zhang, H]]
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[[Category: Zhang H]]
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[[Category: Apoptosis]]
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[[Category: Calcium ion]]
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[[Category: Complex]]
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[[Category: Ef hand]]
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Revision as of 11:39, 2 August 2023

Structure of ALG-2/HEBP2 Complex

PDB ID 5gqq

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