Son of sevenless

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**[[5wfo]], [[5wfq]], [[5fwp]], [[5fwr]] - hSOS1 REM+catalytic domains + HRas + GNP + ligand<br />
**[[5wfo]], [[5wfq]], [[5fwp]], [[5fwr]] - hSOS1 REM+catalytic domains + HRas + GNP + ligand<br />
**[[6d5w]], [[6d5v]], [[6d5m]], [[6bvi]], [[6bvk]], [[6bvj]], [[6bvm]], [[6bvl]], [[6cuo]], [[6d5e]], [[6d59]], [[6d56]], [[6d55]], [[6d5h]], [[6d5g]], [[6d5j]], [[6d5l]], [[6cup]], [[6cur]], [[4nym]] - hSOS1 REM+catalytic domains + HRas + GNP + activator<br />
**[[6d5w]], [[6d5v]], [[6d5m]], [[6bvi]], [[6bvk]], [[6bvj]], [[6bvm]], [[6bvl]], [[6cuo]], [[6d5e]], [[6d59]], [[6d56]], [[6d55]], [[6d5h]], [[6d5g]], [[6d5j]], [[6d5l]], [[6cup]], [[6cur]], [[4nym]] - hSOS1 REM+catalytic domains + HRas + GNP + activator<br />
 +
**[[6scm]], [[6sfr]] - hSOS1 REM+catalytic domains + inhibitor<br />
**[[5ove]], [[5ovg]], [[5ovf]] [[5ovi]], [[5ovh]] - hSOS1 REM+catalytic domains (mutant) + inhibitor<br />
**[[5ove]], [[5ovg]], [[5ovf]] [[5ovi]], [[5ovh]] - hSOS1 REM+catalytic domains (mutant) + inhibitor<br />
-
**[[4nyi]], [[4nyj]] - hSOS1 REM+catalytic domains + HRas + GNP + inhibitor<br />
+
**[[4nyi]], [[4nyj]], [[6v94]], [[6v9j]], [[6v9l]], [[6v9n]], [[6v9m]], [[6v9f]] - hSOS1 REM+catalytic domains + HRas + GNP + inhibitor<br />
**[[6epn]], [[6epm]], [[6epp]], [[6epo]] - hSOS1 REM+catalytic domains + KRas + inhibitor<br />
**[[6epn]], [[6epm]], [[6epp]], [[6epo]] - hSOS1 REM+catalytic domains + KRas + inhibitor<br />

Revision as of 07:39, 11 November 2020

Human SOS1 REM+catalytic domains (olive) complex with HRas (green, purple), GTP, phosphate and Mg++ ion (green) (PDB code 1nvx)

Drag the structure with the mouse to rotate

3D structures of son of sevenless

Updated on 11-November-2020

References

  1. Rojas JM, Oliva JL, Santos E. Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives. Genes Cancer. 2011 Mar;2(3):298-305. doi: 10.1177/1947601911408078. PMID:21779500 doi:http://dx.doi.org/10.1177/1947601911408078
  2. Pierre S, Bats AS, Coumoul X. Understanding SOS (Son of Sevenless). Biochem Pharmacol. 2011 Nov 1;82(9):1049-56. doi: 10.1016/j.bcp.2011.07.072. Epub, 2011 Jul 20. PMID:21787760 doi:http://dx.doi.org/10.1016/j.bcp.2011.07.072

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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