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1bbs

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{{STRUCTURE_1bbs| PDB=1bbs | SCENE= }}
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'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS'''
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===X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS===
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==Overview==
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X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft. Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 1608447 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1608447}}
==About this Structure==
==About this Structure==
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[[Category: Dhanaraj, V.]]
[[Category: Dhanaraj, V.]]
[[Category: Aspartic proteinase]]
[[Category: Aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:18:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:46:52 2008''

Revision as of 15:46, 30 June 2008

Image:1bbs.png

Template:STRUCTURE 1bbs

X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS

Template:ABSTRACT PUBMED 1608447

About this Structure

1BBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins., Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al., Nature. 1992 Jun 11;357(6378):466-72. PMID:1608447

Page seeded by OCA on Mon Jun 30 18:46:52 2008

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