6y2h
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==The crystal structure of human chloride intracellular channel protein 5== | ==The crystal structure of human chloride intracellular channel protein 5== | ||
| - | <StructureSection load='6y2h' size='340' side='right'caption='[[6y2h]]' scene=''> | + | <StructureSection load='6y2h' size='340' side='right'caption='[[6y2h]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y2H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y2H FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6y2h]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y2H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y2H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y2h OCA], [http://pdbe.org/6y2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y2h RCSB], [http://www.ebi.ac.uk/pdbsum/6y2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y2h ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y2h OCA], [http://pdbe.org/6y2h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y2h RCSB], [http://www.ebi.ac.uk/pdbsum/6y2h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y2h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CLIC5_HUMAN CLIC5_HUMAN]] Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLIC5_HUMAN CLIC5_HUMAN]] Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).[UniProtKB:Q8BXK9]<ref>PMID:15184393</ref> <ref>PMID:18028448</ref> <ref>PMID:20335315</ref> <ref>PMID:24781754</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ferofontov A]] | + | [[Category: Ferofontov, A]] |
| - | [[Category: Giladi M]] | + | [[Category: Giladi, M]] |
| - | [[Category: Haitin Y]] | + | [[Category: Haitin, Y]] |
| + | [[Category: Chloride intracellular channel]] | ||
| + | [[Category: Clic]] | ||
| + | [[Category: Metamorphic protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 11:38, 26 August 2020
The crystal structure of human chloride intracellular channel protein 5
| |||||||||||
